Myelodysplastic Syndromes and Ionizing Radiation
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Clonal Hematopoiesis in Aplastic Anemia
WENTY-FIVE YEARS AGO, William Dameshek, T the founder of this journal and one of the most creative minds in American hematology, raised a provocative question: what do aplastic anemia (AA), paroxysmal nocturnal hemoglobinuria (PNH), and acute leukemia have in common?’ His question was prompted by three observations: (1) the frequency of development of PNH in his own patients with AA, (2) the ov...
متن کاملClinical Significance of Cytogenetic Manifestations in Myelodysplastic Syndromes
Myelodysplastic syndrome (MDS) represents a heterogeneous hematopoietic stem-cell disorder that results in abnormal cellular maturation and peripheral blood cytopenias. MDS is characterized by progressive bone marrow failure, which can lead to bleeding, infections, and complications secondary to anemia. Approximately 35% to 40% of patients diagnosed with MDS progress to acute myeloid leukemia (...
متن کاملRange Determination of Antigen Expression in Myeloid, Erythroid and Lymphoid Cell Lineages among Patients with Myelodysplastic Syndrome
Background: Myelodysplastic syndrome is a mixed clonal disorder of bone marrow progenitor cells. Understanding the pattern of the different lineage-specific, immature, and mature markers in myelodysplastic syndrome will help in setting-up the frame of reference to diagnose. Patients and Methods: We compared 60 bone marrow samples from 30 newly-diagnosed patients with myelodysplastic syndrome ...
متن کاملExpression of phosphorylated histone H2AX in blood lymphocytes of patients undergoing angiographic procedures following exposure to X‐rays
Introduction: Coronary angiography is a Diagnostic-Therapeutic method involving ionizing radiation. This method causes to DNA damage with form double stranded breaks which is followed by the phosphorylation of the histone, H2AX. H2AX is a key factor in the repair process of damaged DNA which will accumulate to damage sites. In human cells, H2AX constitutes about 10% of the H2A ...
متن کاملRisk for developing myelodysplastic syndromes in prostate cancer patients definitively treated with radiation.
BACKGROUND Exposure to ionizing radiation has been linked to myelodysplastic syndromes (MDS); it is not clear whether therapeutic radiation doses used for prostate cancer pose an increased MDS risk. METHODS We performed a retrospective cohort study of prostate cancer patients diagnosed between 1986 and 2011 at Cleveland Clinic, comparing those who underwent definitive treatment with radical p...
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تاریخ انتشار 2014